Playmouse is a media group that specializes in sexy entertainment, with a television channel and two print magazines called Playmouse and Pentmouse. Its main stars are Melissa and Clarissa, a pair of mice who had independent modelling careers before joining up and creating one of the most popular names in adult entertainment.

Playmouse and its stars are mentioned in several places throughout the Zoniverse, most prominently with Melissa and Clarissa appearing on Friday Night Party.

Playmouse was an actual furry art gallery in the early 2000s, prominently contributed to by DAQ, Ixbalam and Catsnightmare.